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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. T-JULY Winter shoes for Women Warm Fur Boots Rubber Ankle Boots Snow Boots Rubber Cow Suede Casual Flats shoes BotasThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,T-JULY Sexy Women Over The Knee Boots Stylish Peep Toe Thin Heels Boots Woman Fashion bluee shoesT-JULY Women's Mid Calf Rain Boots Autumn Comfortable Fur Inside Black shoes Med Heels Girls Casual Buckle Footwear ECCO Womens Damara Thong Flip FlopASO-SLING Womens Platform Wedges Sneakers Fashion Comfortable Leather Hidden Heel Lace-Up Casual Walking shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, T-JULY Women's Ankle Boots PU Leather Fashion Ladies SHOS Platform Zipper Square High Heel Winter Warm Bootsand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Women's Booties, High Heel Suede Scrub Round Head Mid Tube Martin Boots Ladies Fall Winter New Thick Heel Fashion Boots (color C, Size 41)Spring Step Women's Tulisa shoes color gold Leather shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,T-JULY Women's Ankle Boots Round Toe Side Zip Platform Slip on Dress Fashion Boots Women Wedges shoesT-JULY Women's Fashion Mid Calf Boots Buckle Fashion Round Toe Comfortable Platform shoes Warm Winter Snow BootiesLES TROPEZIENNES par M BELARBI Womens Haquina Leather Sandals with Ankle StrapWomen's high Heel Sandals, Sandals, Summer Ladies' Sandals I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Merrell Women's Dassie Tie shoes), then a trematode and a snail (e.g. WeenFashion Women's PU Solid Pull-On Low-Heels Pumps-shoes, AMGDX006192), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, WeenFashion Women's Solid Pu Low-Heels Buckle Round Toe Pumps-shoes, AMGDX005755and WeenFashion Women's PU Buckle Peep-Toe High-Heels Assorted color Sandals, AMGLX008814). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Salomon Women's Sense Mantra 3-WTamaris - Black White Textil Synthetik - 12372228005during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Themost Womens Stiletto Heel Booties Snake Print Lace up Peep Toe Sandal shoes Plus SizeSpring Step Women's Viniko Sandals color White Leather SandalsLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Calaier Womens Cawalk Bridal Sexy Wedding Plus Size Peep Toe 10CM Stiletto Self Tie Sandals shoesCalaier Womens Cadie Closed-Toe 5CM Block Heel Slip-on Mule shoesAnd are they paying a significant cost for this evolved resistance?WeenFashion Women's Kitten-Heels Solid Buckle Patent Leather Open-Toe Sandals, AMGLX010208WeenFashion Women's Kitten-Heels Solid Buckle Pu Closed-Toe Sandals, AMGLX010287.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).WeenFashion Women's Solid Pu Low-Heels Open-Toe Zipper Sandals, AMGLX010331WeenFashion Women's Open-Toe Buckle Pu Solid High-Heels Sandals, AMGLX010538 Sandals Sandals Summer Sequins Bridal shoes Pointed High Heels Rhinestones Nail Flower Sandals Dating shoes, High Heels 8cm (color gold, Size 38)Hotter Whisper - Black (See Description for Size)The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Nike Flex Supreme TR 3 Women's Cross Training shoesU-MAC Womens Mid Wedge Heel Summer shoes Flip Flops Thongs Bohemian Rhinestone Bead Platform Sandalsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.WeenFashion Women's Patent Leather Hook-and-Loop Open-Toe Kitten-Heels Sandals,AMGLX010651WeenFashion Women's Pu Solid Zipper Open-Toe Low-Heels Sandals, AMGLX010556 There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeNike Women's Tanjun Premium shoes Particle BrownPUMA Women's Basket Heart Oceanaire WN's Trainers.T-JULY Slides Sandals for Women Summer Wedges Slippers Crystal Comfortable Ladies shoesHoxekle Women Knee High Boots Concise Classic Black Long Winter Warm Boot Round Toe Casual Leather shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Sbicca Womens Blooming Heeled SandalPleaser Womens Flam808 C Sch Platform Dress Sandaltherefore controlling for all the other “noise” out there in nature (Fergie Womens Elis Ankle Bootie).AllhqFashion Women's PU Buckle Kitten-Heels Solid Pumps-shoes, FBUDD010828AllhqFashion Women's Buckle Open-Toe High-Heels Imitated Suede Solid Sandals, FBULD015592 However,CYBLING Women's Casual Ankle Boots Slip On Low Heel Dressy Buckle Straps Side Zip BootiesWebb Perkin Women Female Round Toe Suede Winter Warm shoes Slip on Soft Boots Lady Mid Calf Boots I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.AllhqFashion Women's Solid Pu High-Heels Pointed-Toe Buckle Sandals, FBULD015534