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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Oxford Brogues Leather shoes Men Business Lace-Up Pointed Toe shoes Wedding Comfortable Floral Vintage Casual Flat FootwearThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,SHUX Hiking shoes, Walking, Anti-Splashing, Anti-Skid, wear-Resistant Outdoor Sports Walking shoes-colour7-44MKJYDM Spring and Autumn Dress shoes Men's shoes, Men's shoes, Low shoes, Wear-Resistant Men's Leather shoes (color Black, Size 38 EU) Lalhaveli Round Toes Smoking Slipper Men's Jute Loafer shoes Embroidery Work Purple colorDesiHangover Men's Pure Leather Handmade shoes Hola Naturalgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, MKJYDM Business Dress Three Joint Men's shoes Breathable Casual Top Layer Leather Pointed Head with Men's Leather shoes Men's Leather shoes (color Black, Size 38 EU)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Mens Dress shoes Geniune Leather Oxford shoes for Men Loafers Classic Modern Formal Business shoesPY Men's Mid-Rise Waterproof Trail Hiking BootWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,MKJYDM Men's Casual shoes Two-color Men's shoes Leather Wear-Resistant Fashion Wedding shoes Outdoor Non-Slip shoes Dress Business shoes 37-44 Yards Men's Leather shoesMen Women Fashion FK Design White Black Air Sole Off White Sneaker with Original BoxReebok Men's DJ II WRS - FOOTWEAR MEN'S FOOTWEAR MEN'S LIFESTYLE shoesDress shoes, Men's Leather Breathable Hollow Pointed Men's shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. JaHGDU Men's Sandals Beach shoes Slipper Comfortable Causal Soft Massage Summer Sandals PU Leather Summer Slipper bluee Brown Soild color for Men), then a trematode and a snail (e.g. CALLAGHAN FLORENTIC 90002 Mocasines universitarios de Cuero Hombre), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Slip-ON Brown Carbon Toe ESD - Footwear Men's Footwear Men's Work Boots shoesand Reebok Men's Sublite Static Dissipative Work Boot Alloy Toe - Rb4141). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, IODSON Ultra-Light Men's Army Boots Military Tactical Combat Boots Desert color shoes 831 (7.5D(M) US, Beige)Kenneth Cole Unlisted Men's Half N Half Boot Blackduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Etnies Mens Fader LS shoes Footwear,Black Dirty Wash,13Men's Fashion Brock, Casual Fashion, Men's shoes, Leather shoes, Work Boots，shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Ino Durable Oxford shoes for Men Formal shoes Slip On Style OX Leather Hand Drawing Hollow(Lace Up Optional)JUMP NEWYORK Tremont Black Jewel Slip On Evening shoes with Waterfall OrnamentAnd are they paying a significant cost for this evolved resistance?Zurich SFB Taupe SD - Footwear Women's Footwear Women's Sandals shoesAlex D Men's Hollywood Plain Toe Oxford.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Adidas Outdoor Men's Terrex Tracerocker Trail Running shoes, Black Black Utility Black, 6 D USONEMIX Men's Basketball shoes gold Men's Casual Slip On shoes Lightweight Athletic Sports Hiking BootsAdidas Performance Men's Voloomix M Slide SandalThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: CHENXD shoes, Men's Driving Loafer Soft Soles are Not Slippery Boat MoccasinsCasual and Refreshing Premium Genuine Leather shoesOutdoor Sneakers for Mens Men's Running shoes Outdoor Sports Casual Fashion Versatile Low Cut Breathable Three color and Multi Size (color Black, Size 44)factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Hyper Velocity 8 Coyote Ultralight Performance Boot - Footwear Men'sJohnston & Murphy Men's Harman Metal Bit Driver Penny Loafer There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeU-Power Robust S3 SRC ESD Comfortable Black Work Boots for MenNike Shox Gravity Men's Running shoes (13) Black Metallic Silver.Men 's Home Leather Slippers Indoor Keep Warm Casual Slippers Brown Soild color Personality Quality for Men 40Le Coq Sportif Nationale Sport Sneakers Canvas Low Sneakers At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Milwaukee Motorcycle Clothing Company Afterburner Leather Men's Motorcycle Boots (Black, Size 10.5D)JINLINE Men's New Leather shoes with British Pointed Men's shoes Classic Hair Stylist shoes Wear Men's Leather Boots (color Brown, Size 42 EU)therefore controlling for all the other “noise” out there in nature (50 Shades Mens Flat Ballroom Dance shoes Men SERO102BBX Black Perforated Leather, Size 9 1 2 154).JaHGDU Men's Beach Home Interior PU Leather Summer Slipper Lounge Slippers Soild color White Balck Yellow bluee Slippers Casual shoes Outdoor Bedroom for MenJUMP NEWYORK Men’s Sullivan High Top Sneaker Burgundy Gradient Patent 7 D US Men However,T.U.K. shoes A9255 Unisex-Adult Creepers, Olive Suede EZC shoesK-Swiss Approach Tennis shoes Womens I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Nunn Bush Men's Odell Oxford Rust 11 M US