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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. ASJUNQ Men's Tooling Boots Wear-Resistant Waterproof Hiking shoes Non-Slip Desert Boots Martin Boots Chelsea Boots HighThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Snfgoij Work Boots Mens Waterproof Trainers shoes Martin Boots Autumn and Winter High-top shoes Ankle BootsShiney Men's Genuine Leather Autumn Business Casual Wedding shoes Round Head Office Career DANDANJIE Men's Boots Fashion Martin Boots Youth Lace Up Non-slip Boots for 2018 Fall WinterEasy Go Shopping Men Drive Loafers for Comfortable and Breathable Soft Pure color Boat Moccasins Cricket shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, YXLONG New Summer Leather Men's Sandals Men's Fashion Wild Leather Sandals Outdoor Breathable Beach shoes Menand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. LOVDRAM Men's shoes Spring Fashion Leather One-Legged shoes Casual shoes Men'S shoes Low To Help shoes WildConverse Men's Chuck Taylor All Star Modern, bluee IvoryWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,WLFHM Men's, Sneakers, Spring, Leather shoes, Cow Suede, Casual shoes, Lace-up shoesLEDLFIE Spring Men's Leather shoes Carved Bullock Men's shoes Casual Fashion Dress shoesHush Puppies Mens Pointer Lace Up shoesPalladium Ax_eon Ar Mid, Men’s Ax_eon Ar Mid I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. LEDLFIE Men's Leather shoes Breathable Lace-up Business Casual shoes), then a trematode and a snail (e.g. GTYMFH Spring Men's shoes Microfiber Leather Men's Business shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, LEDLFIE Men's Real Leather shoes Fashion Slip-On Dress shoesand Autumn And Winter Men Pointed Martin Boots High To Help Lazy Boots Casual Men's shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Merrell Men's Terrant Strap SandalMen's Leather shoes，Spring Fall Loafers & Slip-ONS Lazy shoes,Stylish Breathable Driving shoes Peas shoes Comfortable Walking shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). S.Oliver Men's 5-5-13621-21 305 DerbysMen's shoes Leather Loafers shoes Driving shoes Lazy shoes Round Toe shoes Peas shoes Comfortable Fashion Breathable LeisureLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? REPLAY Men's Flat Sole SlidesMzq-yq Sports shoes Men's Running shoes Wild Trend Men's shoes Breathable shoes Casual SlipAnd are they paying a significant cost for this evolved resistance?Autumn Men's shoes Korean Sports shoes Fashion Board shoesAutumn And Winter Men Leather Business Casual Men's shoes Middle-aged shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Kelme Copa Indoor Football Futsal Trainers Mens Yellow Soccer 5 A-Side SneakersSkechers Performance Men's Go Walk 3 Charge Walking shoes Vans Comfycush Old Skool Black True White TrainersWQING Low Rise Hiking BootsHiking shoes Outdoor shoes Waterproof Non-Slip Casual shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Vans Unisex Authentic Checkerboard Canvas TrainersXUE Men's shoes knit Spring Fall Outdoor High-Top Sneakers Hiking shoes Comfort Light Soles Athletic shoes Light Soles Running shoes Breathable Fitness shoes (color B, Size 45)factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.WDDGPZYDX Comfortable spring summer fashion men's casual shoes Breathable adult youth popular shoes sneakers 39-44 sizeCloud 9 Men's Lace-Up Flats Brown Brown There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeZyuQ Ankle boots Men'S Martin Boots Martin shoes Men'S shoes Winter Tooling Men'S Boots Autumn Martin Boots Men'S Boots FashionZQ@QXWinter Jobon Mens Casual leather shoes with cashmere single shoes.Men's casual fashion shoes and cashmere leather casual shoes men's business suits.,brown,Forty-oneJIALUN-shoes Fashion Men's Business shoes Matte PU Leather & Canvas Splice Slip-on Breathable Lined Oxfords(Lace-up Optional) At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, MONKEY BOOTS IN BROWN 6LOVDRAM Men's shoes Spring Men'S shoes Sports shoes Men'S Casual Mesh Breathable shoes Flying Line Running shoes Fashion shoes Newtherefore controlling for all the other “noise” out there in nature (Gant Men's Fresno Slip On Trainers).GLSHI Men Summer Loafers Comfort shoes Mesh Slip-Ons Breathable Grey NewGLSHI Couples shoes Unisex Deck shoes Mens Casual shoes Womens Running shoes Outdoor Exercise Sneakers However,Hey Dude shoes Men's Chan Stretch shoesEl Naturalista Unisex Adults’ N5280 Lux Suede Ocean El Viajero Brogues I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Puma Faas 500 v2, Men’s Low-Top